Antimicrobial activities of pyridinium-tailored pyrazoles bearing 1,3,4-oxadiazole scaffolds
نویسندگان
چکیده
منابع مشابه
Synthesis and Antimicrobial Studies on New Substituted 1,3,4-Oxadiazole Derivatives Bearing 6-Bromonaphthalene Moiety
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Enaminones as building blocks for the synthesis of substituted pyrazoles with antitumor and antimicrobial activities.
Novel N-arylpyrazole-containing enaminones 2a,b were synthesized as key intermediates. Reactions of 2a,b with active methylene compounds in acetic acid in the presence of ammonium acetate afforded substituted pyridine derivatives 5a-d. Enaminones 2a,b also reacted with aliphatic amines such as hydrazine hydrate and hydroxylamine hydrochloride to give bipyrazoles 8a,b and pyrazolylisoxazoles 9a,...
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Abstarct:A simple one-pot synthesis of pyrano[ 2,3-c]pyrazoles was developed by a three-component reaction of various benzaldehydes, malononitrile and 1-phenyl or hydro-3-methyl-1H-pyrazol-5(4H)-one in the presence of N-methyl pyridinium p-toluene sulfonate (NMPyTs) as a catalyst. All of the synthesized compounds were identified by IR, 1H NMR, 13C NMR and mass spectroscopy techniques. In the me...
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Some new b-lactams bearing biologically important morpholine ring have been synthesized by acylation of amino b-lactams in the presence of morpholine-4-carbonyl chloride. These novel β-lactams were prepared under mild reaction conditions without any solvent in short reaction times. Their biological activities have been examined against microbial agents such as Staphylococcus aureus (S. aureus),...
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ژورنال
عنوان ژورنال: Journal of Saudi Chemical Society
سال: 2017
ISSN: 1319-6103
DOI: 10.1016/j.jscs.2017.04.005